Jalees Rehman, MD
Director of Research
Division of Cardiology
University of Illinois at Chicago
Endothelial cells (ECs) in distinct vascular beds exhibit significant heterogeneity in structure and function as well as propensity for vascular disease. Understanding the molecular basis of tissue-specific endothelial gene expression signatures and networks may provide important insights into vascular bed-specific disease mechanisms. Furthermore, analyzing the transcriptomic profiles of ECs within a single vascular tissue bed using single cell RNA-Seq could help identify novel sub-populations of endothelial cells which may demonstrate distinct endothelial functions. This talk will discuss our analysis of transcriptomic heterogeneity of endothelial cells from three vascular beds (lung, brain, heart) at the physiologic state. Lineage tracing of lung endothelial cells following in vivo inflammatory injury allows for the identification of key inflammatory and regenerative pathways. Using single cell RNA Seq, we have also identified novel subpopulations of endothelial cells which appear specifically during inflammatory and regenerative phases of the injury response.
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